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Ask HN: Personalized mRNA cancer vaccines, how real is the pipeline today? 3 by imnotlost | 2 comments on Hacker News. I came across this open-source workflow for designing personalized mRNA cancer vaccines: https://philfung.github.io/openvaxx/ And this recent story about a man who worked with researchers to create a personalized cancer vaccine for his dog: https://ift.tt/6QXgZ1O It got me wondering what the current technology, research, and startup landscape looks like for personalized mRNA medicine in humans. Are any HN people working in this space, or close to it? I’m especially curious about: - how real the pipeline is today outside major institutions - which parts are getting cheaper or more accessible - which parts of the pipeline is being taken over by software and possibly new AI models - where the real bottlenecks are: sequencing, target selection, manufacturing, QC, regulation, or something else - whether anyone is building tools, infrastructure, or startups around more in...

Ask HN: Running legacy IE/ActiveX clients without local admin rights? 6 by Servant-of-Inos | 5 comments on Hacker News. We are currently maintaining a very old client-server architecture. The server collects real-time data from a large number of sensors and controllers, transmitting it to a legacy database under continuous, massive load (writes every few seconds). The problem is the client side. It’s ancient, strictly requires Internet Explorer, and heavily relies on ActiveX. If a standard domain user launches the browser, the data fails to load and the browser completely hangs. It only functions correctly if run with local administrator privileges. Giving users local admin rights is a massive security risk we can't take. Currently, I have a workaround running in production using Task Scheduler to elevate just this specific application without giving the user the actual admin password. I documented the specific approach we are using here: https://ift.tt/h15ZJRz I recently starte...

Ask HN: At what point you decided to pursue your startup fulltime? 3 by kathir05 | 2 comments on Hacker News. We all start with an idea, 0 customers, 0 followers, no clarity on long term on our startups. AT some point, you get conviction, this will work and worth pursuing full-time even though 0 revenue to begin with. For HuntYourTribe, after 2 months, we got 10 portfolios built by strangers and some even kept their link in Github profile. This is it! Even with 0 paying customers, we decided to purse this startup maze full-time, now 10+ paying customers. What's your inflection point?

Rses – cross-resume between Claude Code, Codex, and OpenCode 2 by plawlost | 0 comments on Hacker News. rses claude with codex --last That's it. Reads the Codex session (task, git log, last N turns, session file pointer), builds a structured handoff, launches Claude with it as the first message. Works all 6 directions between Claude Code, Codex CLI, and OpenCode. Shorthand for power users: rses cc w cdx --last ~1200 lines, one npm dep (commander), zero config. Node 22+ built-in SQLite for the session indexes. npm i -g rses-cli https://ift.tt/XSpaulf

Ask HN: How did you figure out what you wanted to do with your life? 4 by icwtyjj | 2 comments on Hacker News. How does one decide their career path or personal goals in life when there are endless options, many of which probably will not work out?

Tired of AI When will this era end? 5 by s_u_d_o | 3 comments on Hacker News. First fancy LLMs, then image generation, then assistants, then agents… When will this end? I’m tired of this hype. Everytime I open HN, or any other community based platform, everyone is talking about AI. Why does this ick me? Am I alone? Simply because i’ve spent my past years, learning how to code, building stuff, reading docs, debugging, scraping through stackoverflow etc…. Am I just, jealous? Or is it really a bad feeling to see something you enjoyed doing, doesn’t seem enjoyable nowadays…. When will this hype end? Will the future be even deeper? I am unable to cope. And every year it gets harder. I just miss the old days, is this an SDDS? Software Developer Dementia Syndrome? All new products, all new launches, everything is now a wrapper of some LLM’s API. I used to hate that everyday we had a JS framework/library… but now I just wish we can get back there, lol. But yeah, this is tech, we have to nor...